Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.41 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 11/20 | 0.40 |
| ▸ | HTT | P42858 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MITF | O75030 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.39 |
| ▸ | NSD2 | O96028 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | CDC25A | P30304 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29835789 | 1.00 | CDC25B (0.66) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL11029625 | 1.00 | CDC25B (0.66) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| SCHEMBL11037610 | 1.00 | CDC25B (0.66) | CDC25BIDO1DNMT1DNMT3LDNMT3A | |
| Buparvaquone SCHEMBL9598809 | 0.83 | CDC25B (0.82) | CDC25BMAPTHTTTDP1LMNA | |
| Buparvaquone SCHEMBL22978 | 0.83 | CDC25B (0.82) | CDC25BMAPTHTTTDP1LMNA | |
| Buparvaquone SCHEMBL21863689 | 0.83 | CDC25B (0.82) | CDC25BMAPTHTTTDP1LMNA | |
| Buparvaquone SCHEMBL30634020 | 0.83 | CDC25B (0.82) | CDC25BMAPTHTTTDP1LMNA | |
| Buparvaquone SCHEMBL11030015 | 0.83 | CDC25B (0.82) | CDC25BMAPTHTTTDP1LMNA | |
| Buparvaquone SCHEMBL23064136 | 0.81 | CDC25B (0.79) | CDC25BMAPTHTTTDP1LMNA | |
| SCHEMBL30372521 | 0.81 | CDC25B (0.63) | CDC25BMAPTHTTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110734368-B | Preparation method of buparvaquone | 新发药业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-110734368-A | Preparation method of buparvaquone | 新发药业有限公司 | 2020-01-31 | — | — | CN | disclosed |
| CN-105198718-A | Preparation method for buparvaquone | SHANDONG CHUANCHENG MEDICINE CO LTD | 2015-12-30 | — | — | CN | disclosed |
| EP-0077551-B1 | 1.4-NAPHTHOQUINONES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL AND VETERINARY FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-06-12 | — | — | EP | disclosed |
| US-4485117-A | ANTIMALARIAL AND ANTICOCCIDIAL; HYDROXYNAPHTHOQUINONES | BURROUGHS WELLCOME CO., A CORP OF NORTH CAROLINA | 1984-11-27 | — | — | US | disclosed |
| EP-0077551-A2 | 1.4-Naphthoquinones, methods for their preparation, pharmaceutical and veterinary formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-04-27 | — | — | EP | disclosed |