Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 1/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029928 | 0.82 | ALDH2 (0.52) | ALDH2ALDH3A1ATMMCL1ALDH1A1 | |
| 4,6,7-Trimethyl-2H-Chromen-2-One SCHEMBL19049403 | 0.67 | KDM4E (0.68) | ALDH2ALDH3A1MCL1ALDH1A1KDM4E | |
| SCHEMBL11028692 | 0.66 | ATM (0.84) | ALDH2ALDH3A1ATMMCL1ALDH1A1 | |
| SCHEMBL25882799 | 0.66 | NOTUM (0.40) | ALDH1A1KDM4ETSHRHPGDNOTUM | |
| SCHEMBL12388121 | 0.65 | ALDH1A1 (0.42) | ATMMCL1ALDH1A1KDM4ETSHR | |
| SCHEMBL12388119 | 0.65 | MCL1 (0.43) | ATMMCL1ALDH1A1KDM4ETSHR | |
| SCHEMBL9463859 | 0.65 | ALDH1A1 (0.68) | ALDH2ALDH3A1ATMMCL1ALDH1A1 | |
| SCHEMBL12656336 | 0.65 | HTR2A (0.49) | NOTUMCYP3A4CYP1A2HIF1A | |
| SCHEMBL29803467 | 0.65 | NOTUM (0.40) | MAOANOTUM | |
| SCHEMBL107921 | 0.65 | NOTUM (0.40) | MAOANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127634-A1 | PYRROLOCOUMARIN DERIVATIVES, THEIR MANUFACTURE AND UTILISATION | KATHOLIEKE UNIVERSITEIT TE LEUVEN (BE) | 1984-12-12 | — | — | EP | disclosed |
| WO-1984002133-A1 | PYRROLOCOUMARIN DERIVATIVES, THEIR MANUFACTURE AND UTILISATION | UNIV LEUVEN KATH (BE) | 1984-06-07 | — | — | WO | disclosed |