Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | NAA50 | Q9GZZ1 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649422 | 0.79 | TRHR (0.43) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11440014 | 0.78 | TRHR (0.47) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11445107 | 0.78 | TRHR (0.47) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL27504186 | 0.77 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL1370995 | 0.76 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11034489 | 0.75 | TRHR (0.44) | TRHR | |
| SCHEMBL14028666 | 0.74 | TRHR (0.61) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11816929 | 0.74 | TRHR (0.38) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL6026783 | 0.73 | TRHR (0.46) | TRHR | |
| SCHEMBL29405912 | 0.73 | TRHR (0.46) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036145-B1 | AN ORALLY ADMINISTERED DRUG FORM COMPRISING A POLAR BIOACTIVE AGENT AND AN ADJUVANT | INTERx RESEARCH CORPORATION (US) | 1985-05-29 | — | — | EP | disclosed |
| EP-0083032-A2 | Rectally administrable suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1983-07-06 | — | — | EP | disclosed |
| EP-0036145-A1 | An orally administered drug form comprising a polar bioactive agent and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-23 | — | — | EP | disclosed |