Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NAA50 | Q9GZZ1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10589314 | 0.86 | CREBBP (0.33) | TRHR | |
| SCHEMBL27504186 | 0.86 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL1370995 | 0.85 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11440014 | 0.81 | TRHR (0.47) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11445107 | 0.81 | TRHR (0.47) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL7775353 | 0.81 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL27448785 | 0.80 | TRHR (0.37) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| Indacrinone SCHEMBL11409556 | 0.79 | CYP3A4 (0.37) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11029979 | 0.79 | TRHR (0.43) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11816929 | 0.79 | TRHR (0.38) | TRHRHDAC3HDAC11HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083032-B1 | RECTALLY ADMINISTRABLE SUPPOSITORY COMPRISING A DRUG AND AN ADJUVANT | MERCK & CO. INC. (US) | 1989-09-20 | — | — | EP | claimed |
| US-4440740-A | α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | claimed |
| EP-0083032-A2 | Rectally administrable suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1983-07-06 | — | — | EP | claimed |
| EP-0036145-A1 | An orally administered drug form comprising a polar bioactive agent and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-23 | — | — | EP | claimed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | claimed |
| EP-0651761-B1 | METHOD FOR MODIFICATION OF RECOMBINANT POLYPEPTIDES | BIONEBRASKA INC (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1170300-A1 | Method for modification of recombinant polypeptides | BIONEBRASKA, INC. (US) | 2002-01-09 | — | — | EP | disclosed |
| US-5656456-A | Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof | BIONEBRASKA, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5635371-A | Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof | BIONEBRASKA, INC. (US) | 1997-06-03 | — | — | US | disclosed |
| EP-0651761-A1 | METHOD FOR MODIFICATION OF RECOMBINANT POLYPEPTIDES | BIONEBRASKA, INC. (US) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994001451-A2 | METHOD FOR MODIFICATION OF RECOMBINANT POLYPEPTIDES | BIONEBRASKA, INC. (US) | 1994-01-20 | — | — | WO | disclosed |
| EP-0083032-B1 | RECTALLY ADMINISTRABLE SUPPOSITORY COMPRISING A DRUG AND AN ADJUVANT | MERCK & CO. INC. (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4464363-A | HYDROXY ARYL- OR HYDROXY ARALKYL ACIDS OR SALTS | MERCK & CO., INC. (US) | 1984-08-07 | — | — | US | disclosed |
| US-4442090-A | ACYLATED AMINO ACID | KYOTO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1984-04-10 | — | — | US | disclosed |
| US-4440740-A | α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0036145-A1 | An orally administered drug form comprising a polar bioactive agent and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-23 | — | — | EP | disclosed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | disclosed |