Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370995 | 0.97 | TRHR (0.41) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL27448785 | 0.91 | TRHR (0.37) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL7649422 | 0.86 | TRHR (0.43) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11816929 | 0.85 | TRHR (0.38) | TRHRHDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11034489 | 0.83 | TRHR (0.44) | TRHR | |
| SCHEMBL27772272 | 0.83 | KLK7 (0.35) | TRHR | |
| SCHEMBL6026783 | 0.82 | TRHR (0.46) | TRHR | |
| SCHEMBL29405912 | 0.82 | TRHR (0.46) | TRHR | |
| SCHEMBL6026780 | 0.82 | TRHR (0.46) | TRHR | |
| SCHEMBL27869228 | 0.82 | TRHR (0.46) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101817870-B | Preparation method of thyrotropin releasing hormone and pharmaceutically acceptable salt thereof | JINAN ZHAODE BIOTECHNOLOGY CO LTD | 2012-04-18 | — | — | CN | disclosed |
| CN-101817870-A | Thyrotropin-releasing hormone and preparation method of pharmaceutically usable salt thereof | JINAN ZHAODE BIOTECHNOLOGY CO LTD | 2010-09-01 | — | — | CN | disclosed |
| CN-1283314-C | Antiparkinsonism drugs | SHIONOGI & CO (JP) | 2006-11-08 | — | — | CN | disclosed |
| CN-1471404-A | anti-Parkinson's disease medicine | 盐野义制药株式会社 | 2004-01-28 | — | — | CN | disclosed |
| CN-1194648-A | Spiro [ 2H-1-benzopyran-2, 4' -piperidine ] -4- (3H) -one derivatives, acid addition salts thereof and pharmaceutical compositions containing them | RICHTER GEDEON VEGY ZETI GYAR (HU) | 1998-09-30 | — | — | CN | disclosed |