Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.81 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | COMT | P21964 | 3/20 | 0.81 |
| ▸ | MMP2 | P08253 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 2/20 | 0.81 |
| ▸ | METAP2 | P50579 | 1/20 | 0.81 |
| ▸ | METAP1 | P53582 | 1/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL11030481 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL29358129 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL29390000 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL11030474 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL9625423 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL48928 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL29598375 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL324753 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL406261 | 1.00 | KDM4E (1.00) | KDM4EALOX12COMTMMP2TSHR | |
| Oxyquinoline SCHEMBL6081972 | 0.98 | KDM4E (0.96) | KDM4EALOX12COMTMMP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557096-B2 | Multistage method for treating metal surfaces prior to dip painting | HENKEL AG & CO. KGAA (DE) | 2013-10-15 | — | — | US | disclosed |
| US-20120186986-A1 | MULTISTAGE METHOD FOR TREATING METAL SURFACES PRIOR TO DIP PAINTING | HENKEL AG & CO. KGAA (DE) | 2012-07-26 | — | — | US | disclosed |