Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.79 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | TACR2 | P21452 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31422682 | 0.85 | OPRM1 (0.75) | OPRM1OPRD1OPRK1OPRL1PLD1 | |
| Hydrochloric Acid SCHEMBL11033620 | 0.85 | OPRM1 (0.60) | OPRM1OPRD1OPRK1OPRL1ADRA1D | |
| SCHEMBL11031960 | 0.83 | OPRM1 (0.62) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| SCHEMBL11032558 | 0.83 | OPRM1 (0.70) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL11033857 | 0.83 | OPRM1 (0.62) | OPRM1OPRD1OPRK1OPRL1PLD1 | |
| SCHEMBL10416342 | 0.81 | OPRM1 (0.68) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| SCHEMBL11030553 | 0.81 | HSD11B1 (0.73) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| SCHEMBL10416823 | 0.81 | OPRM1 (0.62) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL11033809 | 0.80 | HSD11B1 (0.72) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| SCHEMBL10692072 | 0.80 | OPRM1 (0.54) | OPRM1OPRD1OPRK1OPRL1PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |