Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefazolin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.86 |
| ▸ | BLM | P54132 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.86 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 9/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefazolin SCHEMBL16072809 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL3894722 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL2841 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL3424683 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL4930576 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL2842 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL6364010 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL40736 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL15562701 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL38660857 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4379739-A | Electrolytic reduction of cephalosporin p-nitrobenzyl esters | ELI LILLY AND COMPANY (US) | 1983-04-12 | — | — | US | claimed |
| JP-59046291-A | — | — | None | — | — | JP | disclosed |
| EP-0060301-B1 | PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1985-11-27 | — | — | EP | disclosed |
| JP-S5946291-A | NOVEL PREPARATION OF CEPHAZOLIN AND ITS NON-TOXIC SALT | TOUBISHI YAKUHIN KOGYO KK | 1984-03-15 | — | — | JP | disclosed |
| US-4379739-A | Electrolytic reduction of cephalosporin p-nitrobenzyl esters | ELI LILLY AND COMPANY (US) | 1983-04-12 | — | — | US | disclosed |
| EP-0060301-A1 | PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-09-22 | — | — | EP | disclosed |
| US-4327211-A | REACTING WITH 1,3,4-THIADIAZOLE THIOL ESTER OF 1H-TETRAZOLE ACETIC ACID | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1982-04-27 | — | — | US | disclosed |
| US-4314059-A | Process for preparing cephalosporin compounds | SHIBUYA CHISEI | 1982-02-02 | — | — | US | disclosed |
| EP-0038626-A1 | A process for electrolytic reduction of cephalosporin p-nitrobenzyl esters | ELI LILLY AND COMPANY (US) | 1981-10-28 | — | — | EP | disclosed |
| US-4258195-A | Novel thiol esters and process for preparing cephalosporin compounds using same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-03-24 | — | — | US | disclosed |
| US-4229573-A | BACTERICIDES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1980-10-21 | — | — | US | disclosed |
| US-4203972-A | Penicillin composition | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| EP-0004570-A1 | Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1979-10-17 | — | — | EP | disclosed |
| US-4144391-A | REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
| US-4115645-A | SODIUM SULFITE, SODIUM DITHIONITE | ELI LILLY AND COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4028355-A | Cephalosporin purification process | SMITHKLINE CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-3979383-A | Purification process for 7-aminocephalosporins | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3976635-A | Novel esterifying agents, and their production and use | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1976-08-24 | — | — | US | disclosed |
| US-3954745-A | Process for preparing cefazolin | ELI LILLY AND COMPANY (US) | 1976-05-04 | — | — | US | disclosed |