Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefazolin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.86 |
| ▸ | BLM | P54132 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.86 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 9/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefazolin SCHEMBL16072809 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL3894722 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL2841 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL4930576 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL11031717 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL2842 | 1.00 | LMNA (1.00) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL6364010 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL40736 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL15562701 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 | |
| Cefazolin SCHEMBL38660857 | 0.99 | LMNA (0.98) | LMNAPTGS2SLC22A6SLC22A8SLC22A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294521-A1 | METHODS AND SYSTEMS FOR DETERMINING SUITABILITY OF COMPOSITIONS FOR INHIBITING GROWTH OF POLYMICROBIAL SAMPLES | Cap Diagnostics, LLC, DBA Pathnostics (US) | 2023-12-27 | — | — | EP | disclosed |
| CN-117222746-A | Methods and systems for determining suitability of compositions for inhibiting growth of multiple microbial samples | 以诊断途径营业的CAP诊断有限公司 | 2023-12-12 | — | — | CN | disclosed |
| US-20230392185-A1 | METHODS AND SYSTEMS FOR DETERMINING SUITABILITY OF COMPOSITIONS FOR INHIBITING GROWTH OF POLYMICROBIAL SAMPLES | CAP Diagnostics, LLC, dba Pathnostics | 2023-12-07 | — | — | US | disclosed |
| US-20230357818-A1 | METHODS FOR TREATING POLYMICROBIAL INFECTIONS | CAP Diagnostics, LLC, dba Pathnostics | 2023-11-09 | — | — | US | disclosed |
| US-20230357817-A1 | METHODS FOR TREATING POLYMICROBIAL INFECTIONS | CAP Diagnostics, LLC, dba Pathnostics | 2023-11-09 | — | — | US | disclosed |
| US-11746371-B2 | Methods for treating polymicrobial infections | CAP Diagnostics, LLC (US) | 2023-09-05 | — | — | US | disclosed |
| US-20220315975-A1 | METHODS AND SYSTEMS FOR PREPARING THERAPEUTIC SOLUTIONS FOR POLYMICROBIAL INFECTIONS | BANK OF HOPE | 2022-10-06 | — | — | US | disclosed |
| WO-2022178142-A1 | METHODS AND SYSTEMS FOR DETERMINING SUITABILITY OF COMPOSITIONS FOR INHIBITING GROWTH OF POLYMICROBIAL SAMPLES | CAP Diagnostics, LLC, dba Pathnostics (US) | 2022-08-25 | — | — | WO | disclosed |
| WO-2021211746-A1 | METHODS FOR TREATING POLYMICROBIAL INFECTIONS | CAP Diagnostics, LLC, dba Pathnostics (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20210301315-A1 | METHODS FOR TREATING POLYMICROBIAL INFECTIONS | BANK OF HOPE | 2021-09-30 | — | — | US | disclosed |
| EP-3612638-A1 | ASSAY FOR THE COMPREHENSIVE IDENTIFICATION OF ANTIBIOTIC SENSITIVITY | Cap Diagnostics, LLC, DBA Pathnostics (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20190153501-A1 | ASSAY FOR THE COMPREHENSIVE IDENTIFICATION OF ANTIBIOTIC SENSITIVITY | CAP Diagnostics, LLC, dba Pathnostics | 2019-05-23 | — | — | US | disclosed |
| CN-107827957-B | Anti- clinic multi-drug resistant bacteria small peptide | 吴国球 | 2019-02-26 | — | — | CN | disclosed |
| US-10160991-B2 | Assay for the comprehensive identification of antibiotic sensitivity | CAP Diagnostics, LLC (US) | 2018-12-25 | — | — | US | disclosed |
| WO-2018195343-A1 | ASSAY FOR THE COMPREHENSIVE IDENTIFICATION OF ANTIBIOTIC SENSITIVITY | CAP Diagnostics, LLC, dba Pathnostics (US) | 2018-10-25 | — | — | WO | disclosed |
| US-20180305730-A1 | ASSAY FOR THE COMPREHENSIVE IDENTIFICATION OF ANTIBIOTIC SENSITIVITY | CAP DIAGNOSTICS, LLC, D/B/A PATHNOSTICS | 2018-10-25 | — | — | US | disclosed |
| CN-107827957-A | Anti- clinical multi-drug resistant bacteria small peptide | 吴国球 | 2018-03-23 | — | — | CN | disclosed |
| CN-103635193-B | Small molecule RNase inhibitors and methods of use | 罗切斯特大学 | 2017-02-08 | — | — | CN | disclosed |
| US-20100183561-A1 | Biological therapeutic compositions and methods thereof | ARTERIOCYTE MEDICAL SYSTEMS (US) | 2010-07-22 | — | — | US | disclosed |
| WO-2010005557-A2 | BIOLOGICAL THERAPEUTIC COMPOSITIONS AND METHODS THEREOF | ARTERIOCYTE MEDICAL SYSTEMS, INC. (US) | 2010-01-14 | — | — | WO | disclosed |