Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 12/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 12/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 9/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028547 | 1.00 | ENPP2 (0.52) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL11030517 | 0.87 | ENPP2 (0.63) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL11760465 | 0.79 | PTPN1 (0.57) | PTPN2PTPN1PTPN6PTPN11KDM4E | |
| SCHEMBL11029848 | 0.79 | ENPP2 (0.73) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL11028534 | 0.79 | ENPP2 (0.73) | ENPP2S1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL27844768 | 0.77 | PTGS2 (0.57) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL11690859 | 0.77 | PTGS2 (0.57) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL27995689 | 0.77 | PTGS2 (0.57) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL11222681 | 0.77 | PTGS2 (0.57) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL11030761 | 0.76 | HDAC1 (0.43) | PTPN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673882-B2 | Inhibitors of autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2014-03-18 | — | — | US | disclosed |
| WO-2012100018-A1 | INHIBITORS OF AUTOTAXIN | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-07-26 | — | — | WO | disclosed |
| US-20120190650-A1 | Inhibitors of Autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190650-A1 | Inhibitors of Autotaxin | ENPP2, PHPT1, PSPH | ENPP2 1/4885S1PR1 2810/4885S1PR3 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.