Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5710840 | 0.78 | CTSD (0.30) | — | |
| SCHEMBL11223105 | 0.67 | MAPT (0.45) | MAPT | |
| SCHEMBL11028267 | 0.67 | MAPT (0.45) | MAPT | |
| SCHEMBL6229049 | 0.67 | — | — | |
| SCHEMBL25834644 | 0.65 | — | — | |
| SCHEMBL3675121 | 0.56 | PTPN1 (0.31) | MAPT | |
| SCHEMBL13736467 | 0.56 | — | — | |
| SCHEMBL12258622 | 0.56 | PTPN1 (0.36) | — | |
| SCHEMBL19231532 | 0.55 | MAPT (0.46) | MAPT | |
| SCHEMBL13736883 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085158-B1 | PROCESS FOR THE PREPARATION OF CYCLOALKENON DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-06-19 | — | — | EP | disclosed |
| US-4465567-A | Process for the manufacture of 3-hydroxy-2-cycloalken-1-one derivatives | HOFFMANN-LA ROCHE INC. (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0085158-A2 | Process for the preparation of cycloalkenon derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-08-10 | — | — | EP | disclosed |