Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | GALR1 | P47211 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255411 | 0.98 | CHRNB4 (0.47) | CHRNB4CHRNA3CASP3SENP8SENP7 | |
| SCHEMBL9377901 | 0.84 | CHRNB4 (0.46) | CHRNB4CHRNA3TAAR1ESR2GALR1 | |
| SCHEMBL1257281 | 0.82 | CASP3 (0.47) | CHRNB4CHRNA3CASP3SENP8SENP7 | |
| SCHEMBL17070223 | 0.80 | CASP3 (0.46) | CHRNB4CHRNA3CASP3SENP8SENP7 | |
| SCHEMBL3243443 | 0.78 | CASP3 (0.47) | CASP3SENP8SENP7SENP6ACMSD | |
| SCHEMBL28039116 | 0.78 | CHRNB4 (0.56) | CHRNB4CHRNA3TAAR1ESR2GALR1 | |
| SCHEMBL971143 | 0.78 | CHRNB4 (0.49) | CHRNB4CHRNA3ACMSDSERPINE1TDP1 | |
| SCHEMBL18905371 | 0.78 | ACMSD (0.44) | CASP3SENP8SENP7SENP6ACMSD | |
| SCHEMBL19910204 | 0.78 | CHRNB4 (0.49) | CHRNB4CHRNA3ACMSDSERPINE1TDP1 | |
| SCHEMBL417070 | 0.78 | ACMSD (0.51) | CHRNB4CHRNA3ACMSDESR2SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255429-A1 | 3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-10-11 | — | — | EP | claimed |
| WO-2022119888-A1 | 3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-09 | — | — | WO | claimed |
| JP-59042328-A | — | — | None | — | — | JP | disclosed |
| WO-2020120606-A1 | NEW PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-06-18 | — | — | WO | disclosed |
| JP-S5942328-A | 3-FLUOROPHENYLCYCLOHEXENE DERIVATIVE | CHISSO CORP | 1984-03-08 | — | — | JP | disclosed |