Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 5/20 | 0.70 |
| ▸ | F2 | P00734 | 1/20 | 0.69 |
| ▸ | F10 | P00742 | 1/20 | 0.69 |
| ▸ | F7 | P08709 | 1/20 | 0.69 |
| ▸ | CBFB | Q13951 | 5/20 | 0.65 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.63 |
| ▸ | METAP2 | P50579 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970726 | 0.91 | F2 (0.70) | METAP1F2F10F7CBFB | |
| SCHEMBL11034496 | 0.90 | METAP1 (0.58) | METAP1F2F10F7CBFB | |
| SCHEMBL30832867 | 0.87 | CHEK2 (0.82) | METAP1F2F10F7CBFB | |
| SCHEMBL19982677 | 0.84 | F2 (0.65) | METAP1F2F10F7CBFB | |
| SCHEMBL32660766 | 0.84 | F2 (0.65) | METAP1F2F10F7CBFB | |
| SCHEMBL2243148 | 0.83 | CHEK2 (0.80) | METAP1ESR1CHEK2RAB9AHPGD | |
| SCHEMBL7371342 | 0.82 | F2 (1.00) | METAP1F2F10F7CBFB | |
| SCHEMBL27765862 | 0.80 | CHEK2 (0.78) | ESR1CHEK2RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL13221301 | 0.80 | ESR1 (0.59) | METAP1ESR1CHEK2RAB9AHPGD | |
| SCHEMBL179109 | 0.80 | METAP2 (0.60) | METAP1F2F10F7CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4492708-A | Antiviral benzimidazoles | ELI LILLY AND COMPANY (US) | 1985-01-08 | — | — | US | disclosed |