SCHEMBL11035100

SCHEMBL11035100

CCc1ccc(NNCCc2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.50
ATM Q13315 1/20 0.47
TAAR1 Q96RJ0 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
POLB P06746 1/20 0.44
SIGMAR1 Q99720 4/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
LMNA P02545 2/20 0.43
ALOX12 P18054 1/20 0.43
NPC1 O15118 1/20 0.42
KDM1A O60341 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP1A2 P05177 1/20 0.42
HTR1A P08908 1/20 0.42
ADRA2A P08913 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6237452 0.85 L3MBTL1 (0.59) ATMTAAR1L3MBTL1RAB9ASMN1; SMN2
SCHEMBL13185638 0.81 L3MBTL1 (0.68) TP53ATMTAAR1L3MBTL1RAB9A
SCHEMBL25872373 0.78 TP53 (0.59) TP53L3MBTL1RAB9ASMN1; SMN2POLB
SCHEMBL633290 0.76 TP53 (0.78) TP53ATMTAAR1SMN1; SMN2ALOX12
SCHEMBL4454174 0.76 ALDH1A1 (0.43) L3MBTL1RAB9ASMN1; SMN2POLBSIGMAR1
SCHEMBL28200150 0.74 GAA (0.44) TP53TAAR1L3MBTL1RAB9APOLB
SCHEMBL8251058 0.74 GAA (0.74) TP53ATML3MBTL1SIGMAR1ALDH1A1
Ethylbenzene SCHEMBL8093416 0.73 TP53 (0.82) TP53ATMTAAR1SMN1; SMN2ALOX12
SCHEMBL10395199 0.73 SMN1; SMN2 (0.64) ATMTAAR1L3MBTL1RAB9ASMN1; SMN2
SCHEMBL989796 0.73 TAAR1 (0.55) TAAR1L3MBTL1RAB9ASMN1; SMN2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4515783-A BACTERICIDAL ANTIBIOTICS, GROWTH PROMOTERS MERCK & CO., INC. (US) 1985-05-07 US disclosed