Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 11/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990628 | 0.91 | CNR1 (0.57) | TAAR1CNR1IDO1MAPTLMNA | |
| SCHEMBL989861 | 0.91 | CNR1 (0.57) | TAAR1CNR1IDO1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL10770594 | 0.89 | MAPT (0.56) | TAAR1CNR1IDO1MAPTLMNA | |
| SCHEMBL990693 | 0.81 | GAA (0.47) | TAAR1CNR1LMNASMN1; SMN2NPC1 | |
| SCHEMBL1120535 | 0.80 | SMN1; SMN2 (0.57) | CNR1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL989911 | 0.79 | TAAR1 (0.55) | TAAR1CNR1MAPTLMNAALOX12 | |
| Hydrochloric Acid SCHEMBL10514498 | 0.77 | MEN1 (0.46) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5681339 | 0.75 | TAAR1 (0.67) | TAAR1CNR1IDO1MAPTLMNA | |
| SCHEMBL6237452 | 0.74 | L3MBTL1 (0.59) | TAAR1IDO1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9524582 | 0.72 | ALDH1A1 (0.45) | LMNASMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274307-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009120720-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES,INC. (US) | 2009-10-01 | — | — | WO | disclosed |