SCHEMBL11035567

SCHEMBL11035567

Cc1cccc(C)c1NC(=O)c1c(O)ccc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.51
NPC1 O15118 1/20 0.48
POLB P06746 2/20 0.48
PTGER4 P35408 1/20 0.46
KCNJ11 Q14654 1/20 0.45
TSHR P16473 1/20 0.45
HTT P42858 1/20 0.45
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45
HCRTR1 O43613 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.43
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
IDO1 P14902 1/20 0.43
MAPK1 P28482 1/20 0.43
KCNMA1 Q12791 1/20 0.42
HKDC1 Q2TB90 1/20 0.42
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11777297 0.85 MEN1 (0.55) ALOX15NPC1POLBHTTMAPT
SCHEMBL29625679 0.84 ALOX15 (0.56) ALOX15POLBKCNJ11HCRTR1ABCG2
SCHEMBL24953153 0.84 ALOX15 (0.56) ALOX15POLBKCNJ11HCRTR1ABCG2
SCHEMBL23515359 0.80 ALOX15 (0.49) ALOX15NPC1POLBKCNJ11HCRTR1
SCHEMBL4971446 0.78 ALOX15 (0.67) ALOX15NPC1HTTABCG2MAPT
SCHEMBL10822239 0.78 PLK1 (0.56) ALOX15NPC1POLBABCG2MEN1
SCHEMBL8358481 0.77 ALOX15 (0.54) ALOX15POLBABCG2MEN1KMT2A
SCHEMBL7189830 0.76 ABCG2 (0.55) ALOX15POLBABCG2SMN1; SMN2MEN1
SCHEMBL1639535 0.74 ALOX15 (0.55) ALOX15POLBABCG2MAPTMEN1
SCHEMBL9290336 0.74 NPC1 (0.54) NPC1POLBHTTABCG2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59128535-A None JP disclosed
JP-S59128535-A DIAZO COPYING MATERIAL RICOH CO LTD 1984-07-24 JP disclosed