Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11777297 | 0.86 | MEN1 (0.55) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7568133 | 0.82 | KDM4E (0.50) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11035567 | 0.74 | ALOX15 (0.51) | NPC1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL11419220 | 0.73 | ALDH1A1 (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8599970 | 0.73 | ABCG2 (0.50) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL2344209 | 0.73 | NPC1 (1.00) | NPC1RAB9AALDH1A1HPGDHTT | |
| SCHEMBL31411480 | 0.73 | NPC1 (1.00) | NPC1RAB9AALDH1A1HPGDHTT | |
| SCHEMBL1638703 | 0.72 | CA12 (0.60) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL10889856 | 0.71 | MEN1 (0.78) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL17427553 | 0.71 | ABCG2 (0.53) | ALDH1A1HPGDKDM4EHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670787-B1 | CYTOKINE INHIBITORS | ITHERX PHARMA INC (US) | 2012-05-30 | — | — | EP | disclosed |