Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040157 | 0.89 | LMNA (0.60) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| SCHEMBL7634043 | 0.80 | OPRM1 (0.87) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| SCHEMBL11510948 | 0.78 | OPRM1 (0.87) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| Domperidone SCHEMBL43729 | 0.77 | OPRM1 (1.00) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| Domperidone SCHEMBL29373565 | 0.77 | OPRM1 (1.00) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| SCHEMBL11509148 | 0.77 | OPRM1 (1.00) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| SCHEMBL11929195 | 0.77 | OPRM1 (0.78) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| SCHEMBL11163898 | 0.76 | USP2 (0.61) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| SCHEMBL3036994 | 0.76 | LMNA (0.70) | OPRM1OPRK1USP2CYP1A2CYP2D6 | |
| Domperidone SCHEMBL5569643 | 0.76 | OPRM1 (0.98) | OPRM1OPRK1USP2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0058975-B1 | SUBSTITUTED N-(4-INDOLYL-PIPERIDINO-ALKYL) BENZIMIDAZOLONES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-12-12 | — | — | EP | disclosed |
| US-4359468-A | ALSO USEFUL AS HYPOTENSIVE AGE NTS | BOEHRINGER INGELHEIM LTD. (US) | 1982-11-16 | — | — | US | disclosed |
| EP-0058975-A1 | Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1982-09-01 | — | — | EP | disclosed |