SCHEMBL1103602

SCHEMBL1103602

C[Si]1(C)c2ccccc2N(c2c3ccccc3c(-c3cccc4ccccc34)c3c2cnc2ccccc23)c2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 1/20 0.33
POLB P06746 1/20 0.33
KDM4E B2RXH2 1/20 0.31
GPR3 P46089 1/20 0.31
TLR7 Q9NYK1 1/20 0.31
DHFR P00374 1/20 0.30
MET P08581 1/20 0.30
BCHE P06276 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1103443 0.85 TLR7 (0.36) POLBKDM4ETLR7
SCHEMBL1103326 0.84 TLR7 (0.35) KDM4EGPR3TLR7BCHE
SCHEMBL1103608 0.84 POLB (0.35) PDE10APOLBKDM4EGPR3MET
SCHEMBL1103550 0.83 MET (0.37) KDM4EGPR3TLR7METBCHE
SCHEMBL1103611 0.83 MEN1 (0.37) POLBKDM4EGPR3DHFRMET
SCHEMBL1103612 0.83 POLB (0.35) PDE10APOLBKDM4EGPR3
SCHEMBL1103607 0.83 BCHE (0.36) PDE10APOLBKDM4EGPR3MET
SCHEMBL1102819 0.79 TNF (0.40) POLBKDM4EDHFRBCHE
SCHEMBL1103239 0.79 GAA (0.34) POLBKDM4EDHFR
SCHEMBL1103603 0.76 KDM4E (0.36) PDE10AKDM4EGPR3DHFRMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153279-B2 Organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2012-04-10 US disclosed
US-8153279-B2 Organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2012-04-10 US disclosed
US-20100033083-A1 Novel organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2010-02-11 US disclosed
US-20100033083-A1 Novel organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2010-02-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100033083-A1 Novel organic electroluminescent compounds and organic electroluminescent device using the same ORMDL3, OCIAD2, OCIAD1 PDE10A 3477/4885POLB 2825/4885KDM4E 3367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.