SCHEMBL1103550

SCHEMBL1103550

C[Si]1(C)c2ccccc2N(c2c3ccccc3c(-c3ccc4ccccc4c3)c3c2cnc2ccccc23)c2ccccc21

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MET P08581 1/20 0.37
MTOR P42345 3/20 0.32
PIK3CD O00329 2/20 0.32
PIK3CA P42336 2/20 0.32
TLR7 Q9NYK1 1/20 0.32
BCHE P06276 1/20 0.32
NPC1 O15118 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
RECQL P46063 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PIK3CB P42338 1/20 0.31
PIK3CG P48736 1/20 0.31
PDPK1 O15530 1/20 0.31
KDM4E B2RXH2 1/20 0.30
GPR3 P46089 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1103443 0.88 TLR7 (0.36) TLR7LMNAMAPTSMN1; SMN2KDM4E
SCHEMBL1103555 0.84 MET (0.39) METMTORPIK3CDPIK3CANPC1
SCHEMBL1103551 0.84 MET (0.37) METMTORPIK3CDPIK3CATLR7
SCHEMBL1103602 0.83 PDE10A (0.33) METTLR7BCHEKDM4EGPR3
SCHEMBL1103552 0.83 MET (0.36) METMTORPIK3CDPIK3CAMAPT
SCHEMBL1103553 0.83 MET (0.39) METMTORPIK3CDPIK3CABCHE
SCHEMBL1103326 0.82 TLR7 (0.35) TLR7BCHEPDPK1KDM4EGPR3
SCHEMBL1103177 0.80 AKT1 (0.33) LMNAMAPTRAB9AKDM4E
SCHEMBL1102764 0.80 CYP17A1 (0.36)
SCHEMBL1103345 0.79 ADORA3 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153279-B2 Organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2012-04-10 US disclosed
US-8153279-B2 Organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2012-04-10 US disclosed
US-20100033083-A1 Novel organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2010-02-11 US disclosed
US-20100033083-A1 Novel organic electroluminescent compounds and organic electroluminescent device using the same GRACEL DISPLAY INC. (KR) 2010-02-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100033083-A1 Novel organic electroluminescent compounds and organic electroluminescent device using the same ORMDL3, OCIAD2, OCIAD1 MET 4191/4885MTOR 3719/4885PIK3CD 1649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.