Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11040900 | 0.98 | — | — | |
| SCHEMBL9866251 | 0.89 | SIGMAR1 (0.42) | HRH4 | |
| SCHEMBL9867117 | 0.86 | L3MBTL1 (0.43) | — | |
| SCHEMBL10873790 | 0.84 | PTAFR (0.45) | HRH4HRH3 | |
| SCHEMBL11528586 | 0.84 | HRH4 (0.36) | HRH2HRH4HRH3 | |
| SCHEMBL11110534 | 0.82 | HRH4 (0.44) | HRH2HRH4HRH3 | |
| SCHEMBL11109555 | 0.82 | HRH3 (0.31) | HRH3 | |
| SCHEMBL11158305 | 0.82 | HRH2 (0.30) | HRH2HRH4HRH3 | |
| SCHEMBL11645896 | 0.82 | — | — | |
| SCHEMBL7971153 | 0.81 | HRH4 (0.34) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041359-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLYLALKYL GUANIDINES; INTERMEDIATES AND THEIR PREPARATION | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-11-14 | — | — | EP | disclosed |
| US-4443375-A | Tetrahydroimidazo(3,4-c)-1,3-diazocine intermediates for production of guanidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| US-4375435-A | 3-,4-Dihydroimidazo (3,4-c)-1,3-pyrimidines and 4,5-dihydroimidazo (3,4-c)-1,3-diazepines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-03-01 | — | — | US | disclosed |
| EP-0041359-A1 | Process for the preparation of heterocyclylalkyl guanidines; intermediates and their preparation | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-09 | — | — | EP | disclosed |