Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037793 | 0.84 | MAPT (0.49) | PTGS2PTGS1PTGDR2ALDH1A1MEN1 | |
| SCHEMBL11040052 | 0.76 | PTGS2 (0.47) | PTGS2PTGS1PTGDR2ALDH1A1MEN1 | |
| SCHEMBL11043740 | 0.76 | PTGS2 (0.44) | PTGS2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL11040677 | 0.76 | ALOX5 (0.47) | PTGS2ALDH1A1MAPTPPARDKDM4E | |
| SCHEMBL7843752 | 0.70 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL7842996 | 0.70 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL7840244 | 0.70 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL7845155 | 0.70 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL11041686 | 0.70 | HRH3 (0.43) | PTGS2PTGS1PTGDR2PPARD | |
| SCHEMBL11014043 | 0.69 | PTGS1 (0.63) | PTGS2PTGS1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |