Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043740 | 0.95 | PTGS2 (0.44) | ALOX5PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL11040055 | 0.86 | PTGS2 (0.49) | ALOX5PTGS2KDM4EALDH1A1MAPT | |
| SCHEMBL11038889 | 0.81 | PTGS2 (0.49) | ALOX5PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL11040738 | 0.81 | PTGS2 (0.57) | ALOX5PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL11039635 | 0.76 | PTGS2 (0.47) | PTGS2KDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL11039017 | 0.76 | PTGS2 (0.57) | ALOX5PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL11043360 | 0.73 | MAPK1 (0.52) | ALOX5KDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL11037793 | 0.73 | MAPT (0.49) | PTGS2KDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL11466268 | 0.71 | ALOX5 (0.69) | ALOX5PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL6545502 | 0.70 | ALDH1A1 (0.72) | ALOX5KDM4EALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | claimed |
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |