Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.69 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.69 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 3/20 | 0.54 |
| ▸ | RXRB | P28702 | 2/20 | 0.54 |
| ▸ | RXRG | P48443 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27832128 | 0.98 | NR4A1 (0.67) | NR4A2NR4A1NR4A3TSHRSRD5A2 | |
| SCHEMBL9439348 | 0.91 | ALDH1A1 (0.69) | NR4A2NR4A1NR4A3TSHRSRD5A2 | |
| SCHEMBL27613996 | 0.87 | NR4A2 (0.59) | NR4A2NR4A1NR4A3TSHRSRD5A2 | |
| SCHEMBL14505829 | 0.86 | KMT2A (0.61) | NR4A2NR4A1NR4A3TSHRSRD5A2 | |
| SCHEMBL27650204 | 0.84 | NR4A2 (0.65) | NR4A2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL27683133 | 0.84 | ALDH1A1 (0.57) | NR4A2NR4A1NR4A3SRD5A2ALDH1A1 | |
| Hydrogen Peroxide SCHEMBL28758135 | 0.83 | TSHR (0.94) | TSHRALDH1A1KMT2ADAOSLC6A2 | |
| SCHEMBL21533380 | 0.83 | ALDH1A1 (0.61) | NR4A2NR4A1NR4A3TSHRALDH1A1 | |
| SCHEMBL21533306 | 0.82 | SMN1; SMN2 (0.68) | NR4A2NR4A1NR4A3TSHRSRD5A2 | |
| SCHEMBL24047115 | 0.82 | NR4A2 (0.73) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59230788-A | — | — | None | — | — | JP | disclosed |
| JP-S59230788-A | FIXED-TYPE THERMAL RECORDING MATERIAL | MITSUBISHI PAPER MILLS LTD | 1984-12-25 | — | — | JP | disclosed |