Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.65 |
| ▸ | MRGPRX4 | Q96LA9 | 13/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.60 |
| ▸ | RELA | Q04206 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000790 | 0.96 | MRGPRX4 (0.68) | NR4A2MRGPRX4ALDH1A1NPSR1TP53 | |
| SCHEMBL19301712 | 0.89 | MRGPRX4 (0.58) | NR4A2MRGPRX4ALDH1A1NPSR1TP53 | |
| SCHEMBL14505829 | 0.87 | KMT2A (0.61) | NR4A2MRGPRX4ALDH1A1NPSR1TP53 | |
| SCHEMBL27653356 | 0.86 | NR4A2 (0.58) | NR4A2MRGPRX4ALDH1A1NPSR1TP53 | |
| SCHEMBL3315985 | 0.86 | MRGPRX4 (0.68) | MRGPRX4ALDH1A1NPSR1TP53NFKB1 | |
| SCHEMBL10653127 | 0.86 | ALDH1A1 (0.62) | NR4A2MRGPRX4ALDH1A1NPSR1TP53 | |
| SCHEMBL11427053 | 0.84 | ALDH1A1 (0.57) | NR4A2MRGPRX4ALDH1A1NPSR1TP53 | |
| Terephthalic Acid SCHEMBL11039705 | 0.84 | NR4A2 (0.69) | NR4A2ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL13316468 | 0.83 | FOLH1 (0.61) | NR4A2MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL3312463 | 0.83 | MRGPRX4 (0.60) | MRGPRX4ALDH1A1NPSR1TP53NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1906188-A | Phenyl- [ 4- (3-phenyl-1H-pyrazol-4-yl) -pyrimidin-2-yl ] -amine derivatives as IGF-1R inhibitors | NOVARTIS AG (CH) | 2007-01-31 | — | — | CN | disclosed |