Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 15/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11044896 | 0.85 | ALDH1A1 (0.40) | SGMS2ALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL15445355 | 0.84 | STAT3 (0.45) | SGMS2ALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL11042257 | 0.81 | ALDH1A1 (0.42) | SGMS2ALDH1A1KDM4ECYP2C19MAPT | |
| SCHEMBL9827673 | 0.79 | ALDH1A1 (0.33) | SGMS2ALDH1A1LMNA | |
| SCHEMBL11040972 | 0.78 | SMN1; SMN2 (0.46) | SGMS2ALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL8322213 | 0.78 | SGMS2 (0.61) | SGMS2ALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL1376377 | 0.78 | MAOB (0.53) | ALDH1A1LMNAKDM4ECYP1A2CYP2C19 | |
| SCHEMBL22714014 | 0.77 | ALDH1A1 (0.44) | SGMS2ALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL30352684 | 0.77 | ALDH1A1 (0.44) | SGMS2ALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL22713923 | 0.74 | PDE4B (0.42) | SGMS2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |