Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039723 | 0.85 | SGMS2 (0.54) | ALDH1A1L3MBTL1MAPTKDM4ESGMS2 | |
| SCHEMBL11042257 | 0.85 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1MAPTNPSR1KDM4E | |
| SCHEMBL9827673 | 0.84 | ALDH1A1 (0.33) | ALDH1A1SGMS2LMNA | |
| SCHEMBL11637673 | 0.82 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1MAPTNPSR1PKM | |
| SCHEMBL11040633 | 0.80 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1MAPTNPSR1PKM | |
| SCHEMBL11040700 | 0.80 | GAA (0.42) | MAPTKDM4EPOLBCYP1A2 | |
| SCHEMBL1825768 | 0.78 | CA1 (0.33) | — | |
| SCHEMBL11040594 | 0.77 | ALOX5 (0.40) | ALDH1A1L3MBTL1NPSR1KDM4ELMNA | |
| SCHEMBL2610140 | 0.77 | ESR1 (0.42) | ALDH1A1MAPTNPSR1SGMS2LMNA | |
| SCHEMBL3295518 | 0.76 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1MAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |