Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | HRH2 | P25021 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12288130 | 0.85 | DRD3 (0.77) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL12288127 | 0.85 | DRD3 (0.77) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL4667455 | 0.84 | HRH1 (0.67) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL10966316 | 0.83 | ALDH1A1 (0.59) | TDP1HTR2AUSP2ALDH1A1LMNA | |
| SCHEMBL10964662 | 0.81 | HRH1 (0.36) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL2058840 | 0.81 | HRH1 (0.86) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL10653031 | 0.80 | LTA4H (0.44) | HRH1DRD3TDP1HRH2HTR2A | |
| Hydrochloric Acid SCHEMBL9775427 | 0.80 | LMNA (0.60) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL24022700 | 0.80 | HRH1 (0.79) | HRH1DRD3TDP1HRH2HTR2A | |
| SCHEMBL19390112 | 0.80 | HRH1 (0.79) | HRH1DRD3TDP1HRH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060674-B1 | DIHYDROPYRIDINE ANTI-ISCHAEMIC AND ANTIHYPERTENSIVE AGENTS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1985-09-18 | — | — | EP | disclosed |
| US-4430333-A | Dihydropyridine anti-ischaemic and antihypertensive agents | PFIZER INC. (US) | 1984-02-07 | — | — | US | disclosed |
| EP-0060674-A1 | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-09-22 | — | — | EP | disclosed |