Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254783 | 0.82 | MEN1 (0.43) | LMNASMN1; SMN2POLBMAPTHTT | |
| SCHEMBL11038529 | 0.80 | HSD17B10 (0.33) | SMN1; SMN2POLBMAPT | |
| SCHEMBL11254789 | 0.79 | MEN1 (0.40) | SMN1; SMN2POLBMAPTHTTKMT2A | |
| SCHEMBL10924766 | 0.77 | ALDH1A1 (0.54) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL6959645 | 0.73 | ALDH1A1 (0.44) | LMNASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL10911007 | 0.69 | ALDH1A1 (0.46) | LMNAPOLBMAPTKMT2AMEN1 | |
| SCHEMBL10910626 | 0.69 | ALDH1A1 (0.45) | LMNAPOLBMAPTKMT2AMEN1 | |
| SCHEMBL10920420 | 0.68 | ALDH1A1 (0.46) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL10913108 | 0.67 | ALDH1A1 (0.43) | LMNAMAPTKMT2AMEN1RAB9A | |
| SCHEMBL11401431 | 0.67 | ALDH1A1 (0.32) | LMNASMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042566-B1 | 4,4-DISUBSTITUTED 1,4-DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1984-09-05 | — | — | EP | disclosed |
| EP-0042569-B1 | 4,4-DISUBSTITUTED SPIRO-1,4-DIHYDROPYRIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS INTERMEDIATES | BAYER AG (DE) | 1983-10-12 | — | — | EP | disclosed |
| EP-0042566-A1 | 4,4-Disubstituted 1,4-dihydropyridines, process for their preparation and their use in medicaments | BAYER AG (DE) | 1981-12-30 | — | — | EP | disclosed |
| EP-0042569-A1 | 4,4-Disubstituted spiro-1,4-dihydropyridines, process for producing them and their use as intermediates | BAYER AG (DE) | 1981-12-30 | — | — | EP | disclosed |