Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10583768 | 0.82 | CES2 (0.44) | CES2PNMTACP3THRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10386368 | 0.81 | EPHX1 (0.44) | CES2PNMTIDO1TDO2ACP3 | |
| Hydrochloric Acid SCHEMBL11040499 | 0.79 | CES2 (0.45) | CES2IDO1TDO2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL11040287 | 0.77 | BRD4 (0.39) | GAAMAPTSLC6A2SLC6A4 | |
| SCHEMBL30836057 | 0.77 | CES2 (0.49) | CES2PNMTACP3THRBSMN1; SMN2 | |
| SCHEMBL1043810 | 0.77 | CES2 (0.49) | CES2PNMTACP3THRBSMN1; SMN2 | |
| SCHEMBL11044871 | 0.76 | LMNA (0.45) | GAAALDH1A1POLBHPGD | |
| SCHEMBL16024763 | 0.75 | CES2 (0.48) | CES2PNMTACP3THRBSMN1; SMN2 | |
| SCHEMBL3964941 | 0.75 | SMN1; SMN2 (0.48) | CES2PNMTACP3THRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11041992 | 0.75 | LMNA (0.44) | GAAALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |