Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11041992 | 0.98 | LMNA (0.44) | LMNAMMP8POLBMAPK1TSHR | |
| Hydrochloric Acid SCHEMBL11040198 | 0.82 | PTGS1 (0.48) | LMNAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL11043926 | 0.80 | ALDH1A1 (0.39) | LMNAGAAKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL11040499 | 0.79 | CES2 (0.45) | LMNA | |
| Hydrochloric Acid SCHEMBL11040287 | 0.79 | BRD4 (0.39) | LMNAGAA | |
| SCHEMBL4297584 | 0.78 | MMP8 (0.57) | LMNAMMP8POLBMAPK1TSHR | |
| SCHEMBL27590464 | 0.78 | MMP8 (0.57) | LMNAMMP8POLBMAPK1TSHR | |
| SCHEMBL3266292 | 0.78 | MMP8 (0.57) | LMNAMMP8POLBMAPK1TSHR | |
| SCHEMBL279960 | 0.78 | MMP8 (0.57) | LMNAMMP8POLBMAPK1TSHR | |
| SCHEMBL28929528 | 0.77 | MMP8 (0.56) | LMNAMMP8POLBMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-10-08 | — | — | US | disclosed |
| US-7563796-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2009-07-21 | — | — | US | disclosed |
| US-20090042912-A1 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7456186-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2008-11-25 | — | — | US | disclosed |
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042912-A1 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE | BACE1, BACE2, APP | LMNA 766/4885MMP8 1458/4885POLB 1880/4885 |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | LMNA 818/4885MMP8 2553/4885POLB 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.