Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10731488 | 0.90 | ADRB2 (0.54) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10731500 | 0.90 | ADRB2 (0.54) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10731494 | 0.90 | ADRB2 (0.54) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10731482 | 0.90 | ADRB2 (0.54) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL11053844 | 0.90 | ADRB3 (0.56) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL9007073 | 0.90 | ADRB3 (0.56) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL9007077 | 0.90 | ADRB3 (0.56) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL11040417 | 0.89 | ADRB3 (0.55) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10728905 | 0.88 | ADRB1 (0.42) | ADRB2ADRB1ADRA1AADRA1DADRA1B | |
| SCHEMBL10730619 | 0.88 | ADRB1 (0.42) | ADRB2ADRB1ADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040915-B1 | ARYLETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1984-03-21 | — | — | EP | disclosed |
| US-4396627-A | HYPOGLYCEMIC AGENTS, TREATMENT OF OBECITY | BEECHAM GROUP LIMITED (GB) | 1983-08-02 | — | — | US | disclosed |
| US-4385066-A | DIETETICS, HYPERGLYCEMIC AGENTS ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1983-05-24 | — | — | US | disclosed |
| EP-0021636-B1 | SECONDARY AMINES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-01 | — | — | EP | disclosed |
| EP-0040915-A1 | Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-12-02 | — | — | EP | disclosed |
| EP-0021636-A1 | Secondary amines, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-01-07 | — | — | EP | disclosed |