Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 13/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007077 | 1.00 | ADRB3 (0.56) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL9007073 | 1.00 | ADRB3 (0.56) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| Hydrochloric Acid SCHEMBL11040417 | 0.99 | ADRB3 (0.55) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL10773274 | 0.93 | ADRB1 (0.60) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL10772579 | 0.90 | ADRB1 (0.69) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL9007030 | 0.90 | ADRB1 (0.69) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL9006832 | 0.90 | ADRB1 (0.69) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL11039896 | 0.90 | ADRB2 (0.47) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL11039262 | 0.89 | ADRB1 (0.49) | ADRB3ADRB1CYP3A4CYP2D6USP2 | |
| SCHEMBL9631756 | 0.88 | ADRB3 (0.51) | ADRB3ADRB1CYP3A4CYP2D6USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040915-B1 | ARYLETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1984-03-21 | — | — | EP | disclosed |
| US-4385066-A | DIETETICS, HYPERGLYCEMIC AGENTS ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1983-05-24 | — | — | US | disclosed |
| EP-0040915-A1 | Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-12-02 | — | — | EP | disclosed |