Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11043040 | 0.98 | TSHR (0.33) | TSHRKDM4ECES2CES1HPGD | |
| SCHEMBL11044939 | 0.84 | ADRA2A (0.37) | KDM4EMEN1KMT2ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL11039055 | 0.84 | HTR2C (0.35) | KDM4EMAPTRAB9ALMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL11042291 | 0.83 | SMN1; SMN2 (0.37) | TSHRKDM4EHPGDHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL11040444 | 0.82 | MEN1 (0.38) | KDM4EMAPTMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL11042118 | 0.77 | HPGD (0.35) | TSHRHPGDPOLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11043926 | 0.76 | ALDH1A1 (0.39) | KDM4EHPGDMAPTMEN1LMNA | |
| Hydrochloric Acid SCHEMBL11042289 | 0.76 | ESR1 (0.41) | TSHRKDM4ELMNACYP1A2NPSR1 | |
| Hydrochloric Acid SCHEMBL11040499 | 0.74 | CES2 (0.45) | CES2CES1MAPTMEN1LMNA | |
| Hydrochloric Acid SCHEMBL11041726 | 0.73 | CES2 (0.42) | TSHRKDM4ECES2CES1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |