Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189666 | 0.74 | TUBB1 (0.31) | — | |
| SCHEMBL4799105 | 0.73 | APP (0.34) | TDP1 | |
| SCHEMBL4798296 | 0.72 | NPFFR1 (0.44) | — | |
| SCHEMBL7814448 | 0.71 | APEX1 (0.45) | APEX1CA2CA4CA1CA6 | |
| SCHEMBL5613166 | 0.71 | APEX1 (0.45) | APEX1CA2CA4CA1CA6 | |
| SCHEMBL27793545 | 0.67 | VCP (0.50) | TDP1NPSR1 | |
| SCHEMBL16955447 | 0.65 | ALDH1A1 (0.37) | — | |
| SCHEMBL1966924 | 0.65 | APEX1 (0.53) | APEX1CA2CA4CA1CA6 | |
| SCHEMBL27827613 | 0.64 | PTGS1 (0.33) | — | |
| SCHEMBL7170676 | 0.63 | APEX1 (1.00) | APEX1CA2CA4CA1CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |