Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11040043 | 0.98 | BRD4 (0.44) | BRD4CYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL11057303 | 0.90 | MAPT (0.40) | BRD4CYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL11040367 | 0.90 | MAPT (0.40) | BRD4CYP3A4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11059748 | 0.89 | MAPT (0.42) | BRD4CYP3A4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11051850 | 0.89 | MAPT (0.42) | BRD4CYP3A4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11038881 | 0.88 | BRD4 (0.38) | BRD4CYP3A4MAPTGAA | |
| Hydrochloric Acid SCHEMBL11042874 | 0.86 | BRD4 (0.38) | BRD4CYP3A4MAPTALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11038894 | 0.86 | MAOA (0.38) | BRD4CYP3A4MAPTALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL11051967 | 0.86 | MAOA (0.40) | BRD4ALDH1A1MAOACYP2D6HSD17B10 | |
| SCHEMBL11041298 | 0.81 | BRD4 (0.46) | BRD4CYP3A4MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116444-A2 | Improvements in or relating to benzazepine derivatives | ELI LILLY AND COMPANY (US) | 1984-08-22 | — | — | EP | claimed |
| EP-0115961-A2 | Process for preparing benzazepines | ELI LILLY AND COMPANY (US) | 1984-08-15 | — | — | EP | claimed |
| EP-0116444-A2 | Improvements in or relating to benzazepine derivatives | ELI LILLY AND COMPANY (US) | 1984-08-22 | — | — | EP | disclosed |
| EP-0115961-A2 | Process for preparing benzazepines | ELI LILLY AND COMPANY (US) | 1984-08-15 | — | — | EP | disclosed |