Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039942 | 0.85 | KDM4E (0.36) | GAAALDH1A1HTTKDM4ELMNA | |
| SCHEMBL11039085 | 0.84 | HTR2A (0.34) | GAAALDH1A1HTTKDM4ELMNA | |
| SCHEMBL11040699 | 0.84 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNAMAPTKMT2A | |
| SCHEMBL11041678 | 0.83 | GAA (0.35) | GAAALDH1A1KMT2A | |
| SCHEMBL11042257 | 0.81 | ALDH1A1 (0.42) | ACHEALDH1A1HTTKDM4EMAPT | |
| SCHEMBL17321032 | 0.80 | GAA (0.31) | GAA | |
| SCHEMBL11041179 | 0.78 | TDP1 (0.47) | ALDH1A1CYP3A4HTTLMNAMAPT | |
| SCHEMBL30536243 | 0.76 | ALDH1A1 (0.39) | GAAACHEALDH1A1CYP3A4HTT | |
| SCHEMBL11040878 | 0.74 | ACHE (0.30) | ACHE | |
| SCHEMBL2610140 | 0.72 | ESR1 (0.42) | GAAACHEALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |