Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048984 | 0.84 | HPGD (0.40) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL11039354 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL29922664 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL11041797 | 0.76 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26042834 | 0.75 | TDP1 (0.62) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL11041179 | 0.73 | TDP1 (0.47) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL11042257 | 0.72 | ALDH1A1 (0.42) | ALDH1A1TDP1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL2416277 | 0.71 | ALDH1A1 (0.61) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL5037597 | 0.70 | ALDH1A1 (0.48) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL22095405 | 0.69 | MAPT (0.44) | ALDH1A1TDP1L3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |