Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19116731 | 0.80 | MAPT (0.45) | KMT2AMEN1HPGDHTTPTGS2 | |
| SCHEMBL4616451 | 0.74 | KMT2A (0.57) | KMT2AMEN1HPGDHTTPTGS2 | |
| SCHEMBL17446097 | 0.74 | LMNA (0.48) | KMT2AMEN1HPGDHTTCA12 | |
| SCHEMBL4617244 | 0.71 | CA12 (0.67) | KMT2AMEN1HTTPTGS2CA12 | |
| SCHEMBL5672477 | 0.70 | CA12 (0.48) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL5674063 | 0.70 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL17446240 | 0.68 | CYP11B1 (0.50) | KMT2AMEN1HPGDHTTTP53 | |
| SCHEMBL5281877 | 0.67 | KMT2A (0.65) | KMT2AMEN1HTTPTGS2CA12 | |
| SCHEMBL5671527 | 0.67 | PTGS2 (0.56) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL23643023 | 0.67 | GSK3A (0.53) | KMT2AMEN1HPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |