Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11044568 | 1.00 | ADORA2A (0.44) | ADORA2AADORA2BKCNH2HRH3HSD17B10 | |
| SCHEMBL11044466 | 0.99 | KCNH2 (0.44) | ADORA2AADORA2BKCNH2HRH3HSD17B10 | |
| SCHEMBL11041195 | 0.93 | TSHR (0.44) | ADORA2AKCNH2HRH3HSD17B10TSHR | |
| SCHEMBL11046894 | 0.80 | HSD17B10 (0.51) | KCNH2HRH3HSD17B10TSHRKDM4E | |
| SCHEMBL11047298 | 0.78 | HCAR1 (0.43) | KCNH2HRH3HSD17B10TSHRKDM4E | |
| SCHEMBL11047797 | 0.77 | HSD17B10 (0.45) | ADORA2AADORA2BHSD17B10TSHRKDM4E | |
| SCHEMBL11047299 | 0.74 | KDM4E (0.41) | KCNH2HRH3HSD17B10TSHRKDM4E | |
| SCHEMBL11043888 | 0.73 | KDM4E (0.51) | ADORA2AHSD17B10TSHRKDM4ELMNA | |
| SCHEMBL11109630 | 0.72 | HSD17B10 (0.77) | KCNH2HSD17B10TSHRKDM4ELMNA | |
| SCHEMBL10632998 | 0.72 | TUBB4A (0.38) | ADORA2AHSD17B10TSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451448-A | 1-Substituted tricyclic quinazolinones useful as tranquilizers | SANDOZ, INC. (US) | 1984-05-29 | — | — | US | claimed |
| US-4451448-A | 1-Substituted tricyclic quinazolinones useful as tranquilizers | SANDOZ, INC. (US) | 1984-05-29 | — | — | US | disclosed |