Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | SOD1 | P00441 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029193 | 0.85 | TAAR1 (0.44) | TAAR1 | |
| SCHEMBL2093441 | 0.82 | SOD1 (0.46) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL14510698 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL9011837 | 0.79 | PPARA (0.57) | — | |
| SCHEMBL5253611 | 0.79 | PPARA (0.57) | — | |
| SCHEMBL9488681 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL30358275 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2SOD1MAPK1 | |
| SCHEMBL29908907 | 0.77 | TAAR1 (0.62) | TAAR1IDO1AGXT | |
| SCHEMBL12497 | 0.77 | TAAR1 (0.62) | TAAR1IDO1AGXT | |
| SCHEMBL7477628 | 0.76 | TP53 (0.55) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |