Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 10/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 9/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11047780 | 0.82 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11053734 | 0.77 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL11039548 | 0.77 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11047792 | 0.75 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11046783 | 0.70 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL30357746 | 0.70 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL1741683 | 0.70 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11167186 | 0.70 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11788656 | 0.68 | ALDH1A1 (0.54) | LMNAMEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL11859273 | 0.67 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4436913-A | HYPOTENSIVE AGENTS | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1984-03-13 | — | — | US | claimed |
| WO-1982000824-A1 | 1H AND 2H INDAZOL DERIVATIVES AND MEDICAMENTS CONTAINING THEM | GEISSMANN F | 1982-03-18 | — | — | WO | disclosed |