Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.46 |
| ▸ | TUBB | P07437 | 3/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28900604 | 0.98 | TUBB1 (0.47) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8920272 | 0.86 | SMN1; SMN2 (0.44) | CYP1A2BRD4 | |
| SCHEMBL8933986 | 0.82 | CYP3A4 (0.43) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8934082 | 0.82 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8778636 | 0.81 | ALDH1A1 (0.46) | — | |
| SCHEMBL9128080 | 0.80 | NPC1 (0.44) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9041895 | 0.79 | TUBB1 (0.46) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11042512 | 0.79 | TUBB1 (0.49) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28900582 | 0.79 | CA2 (0.53) | ACHEMAPTCA9 | |
| SCHEMBL7955079 | 0.78 | PTGS2 (0.46) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |