Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | QPCT | Q16769 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14397502 | 0.84 | ALDH1A1 (0.65) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11045234 | 0.80 | GRIK1 (0.45) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL7889980 | 0.77 | ALDH1A1 (0.63) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL12713434 | 0.76 | LMNA (0.64) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11048979 | 0.76 | QPCT (0.52) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL12713417 | 0.76 | ALDH1A1 (0.61) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL12713422 | 0.75 | QPCT (0.65) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL13236187 | 0.74 | MAPT (0.62) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL12713468 | 0.74 | QPCT (0.61) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL12713416 | 0.73 | LMNA (0.63) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4442289-A | ANTIASTHMA | HOFFMANN-LA ROCHE INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4376121-A | Antiallerigically-active imidazothienopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |