Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CCKBR | P32239 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | FPR1 | P21462 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperacillin SCHEMBL11045255 | 1.00 | LMNA (0.76) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL9374347 | 0.98 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL717962 | 0.98 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL34180 | 0.98 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL10956851 | 0.98 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL536988 | 0.98 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL1665895 | 0.98 | LMNA (0.77) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL10692696 | 0.96 | LMNA (0.75) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL24437361 | 0.93 | MEN1 (0.77) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL33894 | 0.93 | MEN1 (0.77) | LMNAKMT2AMEN1CCKBRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488994-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1984-12-18 | — | — | US | disclosed |
| US-4432903-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4377524-A | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |