Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CCKBR | P32239 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | FPR1 | P21462 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperacillin SCHEMBL536988 | 0.99 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL717962 | 0.99 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL34180 | 0.99 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL9374347 | 0.99 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL10956851 | 0.99 | LMNA (0.78) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL11045258 | 0.98 | LMNA (0.76) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL11045255 | 0.98 | LMNA (0.76) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL10692696 | 0.97 | LMNA (0.75) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL3225030 | 0.93 | MEN1 (0.76) | LMNAKMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL261048 | 0.93 | MEN1 (0.76) | LMNAKMT2AMEN1CCKBRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112409381-B | Piperacillin sodium and tazobactam sodium co-amorphous substance and preparation method thereof | 山东安信制药有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-112409381-A | Piperacillin sodium and tazobactam sodium co-amorphous substance and preparation method thereof | 山东安信制药有限公司 | 2021-02-26 | — | — | CN | disclosed |
| EP-2896625-B1 | COCRYSTAL OF PIPERACILLIN SODIUM AND SULBACTAM SODIUM AND PREPARATION METHOD THEREOF, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF | BEIJING XINTIANYU TECH DEV CO LTD (CN) | 2017-03-01 | — | — | EP | disclosed |
| US-9499565-B2 | Cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing same and uses thereof | BEIJING XINTIANYU TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2016-11-22 | — | — | US | disclosed |
| US-20150299222-A1 | COCRYSTAL OF PIPERACILLIN SODIUM AND SULBACTAM SODIUM AND PREPARATION METHOD THEREOF, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF | XIANGBEI WELMAN PHARMACEUTICAL CO., LTD. (CN) | 2015-10-22 | — | — | US | disclosed |
| EP-2896625-A1 | COCRYSTAL OF PIPERACILLIN SODIUM AND SULBACTAM SODIUM AND PREPARATION METHOD THEREOF, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF | Beijing Xintianyu Technology Development Co., Ltd. (CN) | 2015-07-22 | — | — | EP | disclosed |
| CN-102898438-B | Eutectic of Piperacillin sodium and Sulbactam sodium, preparation method thereof, pharmaceutical composition containing eutectic and application of pharmaceutical composition | BEIJING XINTIANYU TECHNOLOGY DEV CO LTD | 2014-12-24 | — | — | CN | disclosed |
| CN-102898438-A | Eutectic of Piperacillin sodium and Sulbactam sodium, preparation method thereof, pharmaceutical composition containing eutectic and application of pharmaceutical composition | BEIJING XINTIANYU TECHNOLOGY DEV CO LTD | 2013-01-30 | — | — | CN | disclosed |
| WO-2011040386-A1 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM MONOHYDRATE | 富山化学工業株式会社 (JP) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011040386-A1 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM MONOHYDRATE | 富山化学工業株式会社 (JP) | 2011-04-07 | — | — | WO | disclosed |
| US-20100063273-A1 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM | TOYAMA CHEMICAL CO., LTD (JP) | 2010-03-11 | — | — | US | disclosed |
| EP-2128162-A1 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM | Toyama Chemical Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |