Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11042987 | 0.98 | MAPK14 (0.69) | MAPK14NPC1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL11041741 | 0.89 | MAPK14 (0.57) | MAPK14NPC1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL11042390 | 0.88 | MAPK14 (0.56) | MAPK14NPC1MEN1KMT2ALMNA | |
| SCHEMBL11062358 | 0.87 | SIGMAR1 (0.58) | MAPK14NPC1MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11039487 | 0.86 | SIGMAR1 (0.57) | MAPK14NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL16573702 | 0.84 | MAPK14 (1.00) | MAPK14NPC1MEN1KMT2ALMNA | |
| SCHEMBL11071009 | 0.82 | DRD3 (0.66) | MEN1KMT2APDE3BPDE3ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11041259 | 0.81 | DRD3 (0.65) | MEN1KMT2APDE3BPDE3ASIGMAR1 | |
| SCHEMBL5407412 | 0.81 | MAPK14 (0.70) | MAPK14NPC1MEN1KMT2ALMNA | |
| SCHEMBL11067206 | 0.81 | HRH3 (0.52) | MAPK14NPC1MAPK1ALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |