Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.59 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.59 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.59 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.59 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.59 |
| ▸ | CCR2 | P41597 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16573702 | 0.82 | MAPK14 (1.00) | MAPK14NPC1MEN1LMNATSHR | |
| SCHEMBL5411088 | 0.81 | ROCK2 (0.73) | ROCK2ROCK1LMNASMN1; SMN2CCR2 | |
| SCHEMBL31581176 | 0.81 | HPGD (0.66) | ROCK2ALDH1A1DDR1 | |
| SCHEMBL5404960 | 0.81 | ROCK2 (0.67) | ROCK2ROCK1MAPK1KMT2APRKAA1 | |
| SCHEMBL5416737 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1TSHRMAPK1KMT2A | |
| SCHEMBL11045581 | 0.81 | MAPK14 (0.72) | MAPK14NPC1MEN1LMNATSHR | |
| SCHEMBL5407658 | 0.80 | ROCK2 (0.60) | ROCK2ROCK1MAPK1PRKAA1CCR2 | |
| SCHEMBL29995820 | 0.80 | HPGD (0.68) | NPC1ROCK2SMN1; SMN2ALDH1A1DDR1 | |
| SCHEMBL15243010 | 0.80 | HPGD (0.68) | NPC1ROCK2SMN1; SMN2ALDH1A1DDR1 | |
| SCHEMBL5417164 | 0.79 | ROCK2 (0.67) | ROCK2ROCK1MAPK1PRKAA1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| US-20040102437-A1 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
| EP-1256574-A1 | NITROGEN-CONTAINING COMPOUNDS HAVING KINASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | MAPK14 156/4885NPC1 837/4885ROCK2 2/4885 |
| US-20040102437-A1 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | TNK2, ROCK1, ROCK2 | MAPK14 101/4885NPC1 2205/4885ROCK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.