Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045867 | 1.00 | DRD2 (0.42) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL11301230 | 0.80 | DRD2 (0.43) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL4537434 | 0.73 | SLC6A4 (0.51) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL7186275 | 0.69 | KDM4E (0.46) | KDM4E | |
| SCHEMBL10991961 | 0.69 | DRD2 (0.52) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL1840347 | 0.69 | DRD2 (0.58) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10373053 | 0.68 | DRD2 (0.55) | DRD2DRD4DRD3GRM2HTR1A | |
| Hydrochloric Acid SCHEMBL1836699 | 0.68 | DRD2 (0.57) | DRD2DRD4DRD3GRM2HTR1A | |
| Bromide SCHEMBL10365464 | 0.68 | DRD2 (0.57) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL11046678 | 0.67 | DRD2 (0.47) | DRD2DRD4DRD3GRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558056-A | PSYCHOLOGICAL DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4524074-A | TREATMENT OF PSYCHOSES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | disclosed |