Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940371 | 0.81 | HTR1A (0.45) | DRD2HTR1AHTR2A | |
| SCHEMBL10986491 | 0.80 | DRD2 (0.67) | DRD2DRD4DRD3GRM2HTR1A | |
| Hydrochloric Acid SCHEMBL7318328 | 0.75 | DRD2 (0.53) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL11046661 | 0.74 | DRD2 (0.42) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10986480 | 0.74 | DRD2 (0.45) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10373053 | 0.73 | DRD2 (0.55) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10364952 | 0.69 | DRD2 (0.57) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10991961 | 0.68 | DRD2 (0.52) | DRD2DRD4DRD3GRM2HTR1A | |
| Bromide SCHEMBL10365633 | 0.68 | DRD2 (0.56) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL11045873 | 0.67 | DRD2 (0.42) | DRD2DRD4DRD3GRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558056-A | PSYCHOLOGICAL DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4524074-A | TREATMENT OF PSYCHOSES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | disclosed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | disclosed |